Association of Nonfibrillar Amyloid Oligomers with Drusen of Aging and Age-related Macular Degeneration
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چکیده
منابع مشابه
Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers.
Protein misfolding and aggregation are thought to underlie the pathogenesis of many amyloid diseases, such as Alzheimer and Parkinson diseases, whereby a stepwise protein misfolding process begins with the conversion of soluble protein monomers to prefibrillar oligomers and progresses to the formation of insoluble amyloid fibrils. Drusen are extracellular deposits found in aging eyes and in eye...
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